For The Next Day Or So You may resume normal activities immediately, but no strenuous upper body movement, including heavy lifting, for 24 hours. Take Tylenol every 4-6 hours for any mild discomfort. Ice for the first 12 hours post biopsy, then apply heat to the biopsy site to keep swelling to a minimum and also help relieve any discomfort. Mild oozing from the biopsy site and skin discoloration are common. If more pronounced bleeding occurs, lay down, hold firm pressure with a clean towel and ice for a least 15 minutes. If bleeding continues after that, do not hesitate to call us, though know that you are in no danger. Aspirin and non-steroidal anti-inflammatory medications may be resumed in 24 hours.